Tadalafil
Tadalafil
Tadalafil is used to treat erectile dysfunction (ED) and pulmonary hypertension in men.
Delivery
Clinical Trials
effect
Tadalafil (C22H19N3O4), with a molecular weight of 389.4, has been widely used to treat erectile dysfunction (ED) in men since 2003, marketed as Cialis. In 2008, Eli Lilly sold its commercial rights for the treatment of pulmonary arterial hypertension (PAH) to United Therapeutics. In June 2009, the U.S. Food and Drug Administration (FDA) approved tadalafil for the treatment of PAH in the United States, marketed as Adcirca hypertension. Tadalafil was first marketed as an ED treatment in 2003. It takes effect 30 minutes after administration, with effects lasting up to 2 hours, and can last up to 36 hours, unaffected by food. The usual dose of tadalafil is 10 mg or 20 mg, with a recommended starting dose of 10 mg. Dosage adjustments should be made based on patient response and adverse reactions. Pre-marketing studies showed that after 12 weeks of oral administration of 10 mg or 20 mg of tadalafil, the response rates were 67% and 81%, respectively. Multiple studies have shown that tadalafil is effective in treating erectile dysfunction (ED).
Function
Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual intercourse. ED has become one of the most serious health problems affecting men worldwide. Approximately 150 million men globally suffer from some degree of ED, and this number is projected to double by 2025. Phosphodiesterase type 5 (PDE5) inhibitors are important medications for treating male erectile dysfunction (MED). Currently, there are three main PDE5 inhibitors on the market: sildenafil (brand name: Viagra), vardenafil (brand name: Levitra), and tadalafil (brand name: Cialis). In addition, other clinical applications of PDE5 inhibitors, such as the treatment of pulmonary hypertension, are under development and investigation. Since their market launch, sales of PDE5 inhibitors have been steadily increasing year by year.
【Specifications and Dosage】
Erectile dysfunction: This product is a film-coated tablet, available in 10 mg and 20 mg specifications. The recommended dose is 10 mg daily. If the 10 mg dose is ineffective, the dose can be increased to 20 mg. Take 0.5–12 hours before sexual activity.
Pulmonary Hypertension: 40 mg daily.
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Market Expansion
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